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Finally, the tetrameric assembly of XCL reveals a complex network of protomer protomer interfaces and generates a large, hydrated cavity of 1000 Å3, which may become accessible to larger solutes after a small conformational change of the protein.
During this process, the replication fork and its damage intermediates, now PCNA- and RFC-deficient, may become accessible for XPA binding.
35 In this way, messages may become accessible to people who would not ask for help because they are proud or isolated.
Whether such variability is related to experience during the development of the animal and/or individual differences in behavioral capacities is an important question that may become accessible to future noninvasive imaging studies (see below).
As this alternative protocol allows preparing the target molecules from bromoprecursors rather than from aminoprecursors, the shortest bridging ligand (1ditz) may become accessible as well, but this will be the subject of further investigations that go beyond the scope of this paper.
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Recall that large r are in fact unrealistic in experimental techniques available today, but may well become accessible in the future.
Certain antibody epitopes on EpCAM may only become accessible when accessory proteins are reduced on malignant cells or when EpCAM upon high-level overexpression outnumbers its protein partners.
Incubation of two different monomers with the cyclase produces hybrid dimers and trimers, providing the first evidence that conglobatin analogs may in future become accessible through engineering of the polyketide synthase.
Even federally guaranteed student loans may become less accessible: Sallie Mae, the largest lender, has just announced that it will charge fees for loan applications.Some congressmen want the government to buy up securities backed by student debt, and the federal education department may step in as a lender of last resort.
According to our simulated spectra, bright excited states may become optically accessible at low temperatures in hybridization regimes where intermixing with the ground state is achieved.
This neutralization could loosen the contact between negatively charged DNA and lysine-rich histones so that nucleosomal DNA may become more accessible to transcription factors.
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