But even as it gains momentum, the initiative may be having untoward consequences.
"This should not be an issue unless there may be something untoward in these emails".
Provision of high doses of fish oil and purified EPA may be limited by untoward gastrointestinal side effects, which, in some cases, may be managed by dose reduction or pancreatic enzyme supplements (Barber, 2001).
Enthusiasm, based on the pathophysiological rationale for their administration, has been progressively limited by the results of clinical research with controlled trials and registries showing that their administration may be attended by untoward effects and increased mortality.
However, efficient drug delivery and excellent release potential of these delivery systems may be hindered by possible untoward side effects.
Hypomyelination and increased seizures observed in BACE1 -/- mice have raised concerns that therapeutic BACE1 inhibition may be associated with similar untoward effects in humans.
Even in the case of PD, such heterotopically transplanted cells release dopamine in an unregulated way and may be responsible for various untoward complications associated with the current cell transplantation strategy (e.g., the dyskinesias observed in Parkinsonian patients receiving foetal cells transplants; [ 21– 21]).
These untoward effects may be harmful to the patient.
Taken together, this suggests that an interrupted schedule of antiangiogenic TKIs with a short half-life may be helpful in reversing the untoward effect on tumour vasculature and may optimise the intratumoural delivery of chemotherapeutic agents and restore tumour sensitivity.
A number of writers, primarily in the field of psychophysiology, have suggested that breast cancer may be related to a variety of untoward psychological states and that these may be related in turn to having experienced misfortune in the social milieu.
