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Nitric oxide synthase (NOS) may be uncoupled to produce superoxide rather than nitric oxide (NO) under pathological conditions such as diabetes mellitus and insulin resistance, leading to cardiac contractile anomalies.
The comprehensive analysis of abundance and expression patterns of the GOIs presented here, demonstrates that gene expression may be uncoupled from translational and protein activity levels.
This finding suggests Nocturnin may be uncoupled from the regulation of the core clock machinery or influenced by other signals that are dominant to the clock in this situation.
Hence, the acquisition by this clone of its particular set of virulence determinants is possibly recent in time, consistent with epidemiological data [12], and the pathogenicity of clone CC23K1 may be uncoupled from any particular adaptation to humans.
Western blot analysis revealed that L94A induced EGFR phosphorylation as well as the phosphorylation of ERK and AKT (substrate of PI3K) in a manner similar to that of wild type and Q83A (Fig. 3), suggesting that flagellin-induced EGFR activation may be uncoupled from NF-κB and other inflammatory pathways in HCECs.
This suggests that cox2 duplication may be uncoupled with maleness.
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The fact that the introduction of a single cytokine could not reproduce this effect despite its proangiogenic ability suggests that in this chronic setting, functional improvement and therapeutic angiogenesis may be specific and separate components and may thus be uncoupled.
These altered circuits may then be uncoupled from the original pathways to allow the novel functions without affecting the original system.
In fact, the movements of the clamps and the mismatch-binding domains may well be uncoupled.
Mind may also be uncoupled from Sensorium and Brain during journeying to the 'spirit realm', in the case of shamans and modern-day shamanic practitioners.
It is worth noting that these experiments uncouple two steps of the ligation cycle that may not be uncoupled in vivo and thus whether this will also be true in the context of a full ligation cycle in cells is yet to be tested.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com