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First, endothelial function may be systemically impaired in patients with RCVS to a greater extent than that in migraineurs [3, 14, 15].
In concept, they may be systemically important, but they will be taken over by the government if they, in fact, failed or failing.
A complement may be systemically linked to the focal innovation so that the two need to co-develop for future iterations of the product or service offering (de Figueiredo and Teece 1996).
It is possible that population sub-groups with limited access to technology may be systemically underrepresented in data thus the need of sound statistical analysis is not obviated due to the large size of data.
Several studies have shown QDs may be systemically distributed and may accumulate in organs and tissues.
Although few in vivo studies exist, they suggest that QDs may be systemically distributed in rodent animal models and accumulate in a variety of organs and tissues.
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This study shows that alterations in the MMP and TIMP system may be measured systemically in patients with rotator cuff tears, and this knowledge may help in future development of diagnostic and prognostic disease markers.
Molecules, with limited oral bioavailability, may be delivered systemically through the lungs.
Given that connective tissue is a major component of normal breast tissue, it cannot be excluded that such phenomena may be observed systemically.
The latter issue, other than lesion site-specific application, may be addressed systemically by exploiting the concept of synthetic lethality and tumor addiction.
We cannot preclude, however, the possibility that these cytokines may be active systemically at concentrations below the sensitivity limit of current assays.
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