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ADM clearance may be receptor (ADM receptor) dependent.
One difficulty may be receptor redundancy that prevents the straightforward identification of receptors by single knockdowns.
There is considerable evidence that the ECLs are important for the binding of peptide agonists to secretin-like GPCRs but the details may be receptor specific.
The etiology underlying the attenuated parasympathetic responsiveness in the hearts of offspring of obese dams may be receptor independent given that there were no differences in the protein expression of the predominant muscarinic (M2) acetylcholine receptor between groups.
Despite this evidence, the effect of ligands on formation, organization and stability of receptor oligomers, as well as the role of other cellular proteins, is not well understood and may be receptor subtype specific (Angers et al, 2000; Cheng and Miller, 2001; Latif et al, 2002; Zhu et al, 2002; Roess and Smith, 2003; Law et al, 2005).
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It was demonstrated in our works [17, 18], conducted in vitro using the isolated preparations of the stomach, circular smooth muscles of the caecum, and myometrium of rats, that the targets of titanium dioxide suspension with the size of nanoparticles of 21 ± 5 nm may be receptor-dependent regulatory mechanisms of smooth muscle cells.
Although it has been suggested that a G protein heterotrimer is too large to signal via a monomeric GPCR, monomeric receptors have been shown to signal efficiently [ 8], although this ability may be receptor-specific.
DA itself is able to produce a calcium signal within cells that may be receptor-mediated, causing release from intracellular calcium stores (in neurons— or receptor-independent in astrocytes, or possibly due to opening of voltage-dependent calcium channels inducing exogenous calcium influx.
They concluded with the hypothesis that specific glycolipids may be receptors for interaction with fibronectin [ 29].
The source of the AMPARs required for LTP expression may be receptors present in intracellular stores [ 10, 49].
Initiators may be receptors, transcription factors, enzymes or other proteins involved in protein-protein interactions (Aravind et al. 1999).
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