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One factor may be proximity, because AmphoB is endocytosed quite rapidly leading to its concentration in the late endosomes and lysosomes, the areas of IFITM3's highest concentrations.
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If there is reason for optimism in the Caribbean, it may be the proximity of the United States.
The D4S substitution was selected over the D4Y substitution because a tyrosine substitution in position 5 (P5Y) also showed significant improvement, which suggests there may be a proximity effect of tyrosine substitution in this region of the peptide.
It may be that proximity is more important in deprived populations or areas, where physical access is limited by walking or public transport.
Second, spatial variables can have different meaning in different settings; in rural areas, for example, proximity to major roads may be correlated with proximity to parking lots, industrial areas, and other sources, which is less likely in urban areas.
Within the nucleus, DNA sequences that are not proximal in sequence may be brought into proximity by the three-dimensional looping of chromatin.
This difference in location-dependent survival of allogeneic tissue may be associated with proximity to the synovium.
This study shows that soil invertebrate assemblages may be altered in proximity to roads surfaced with calcareous gravel.
On the one hand, the routes may be determined by proximity – spreading to nearby places – or by hierarchical levels – spreading between places in a stepwise manner.
Helix-packing model of EcNhaA based on cross-linking data suggests, that in the three dimensional structure of NhaA, residues that affect the pH response may be in close proximity, forming a single pH sensitive domain.
The higher exchange rate of His45 in DHFR-MTX compared to apo-DHFR may be its close proximity to the carboxyl group of Glu17.
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