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Refractory period may be prospectively studied in a reasonable cohort before its application as criteria for diagnosing SUNCT.
The population included in the CARDIAC study will be prospectively followed for a scheduled follow-up period of 4 years, and the data of the CARDIAC-PRO study will then provide definite evidence whether ADMA may be prospectively determined as a cardiovascular risk factor.
Patients displaying deteriorating trends in these key clinical variables may be prospectively identified as at higher mortality risk.
Previous studies suggest that circulating levels of interleukin-18 (IL-18) may be prospectively related to risk of coronary heart disease (CHD) in the general population.
Subsequently, the tumor-initiating activity can be enriched by sorting cells on the basis of intrinsic characteristics and may be prospectively isolated based on a specific cell surface phenotype [ 7].
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These autoantibodies and their clinical long-term relevance may also be prospectively validated in this RCT.
While biopsy of the metastatic site may not be prospectively able to demonstrate improved outcome for each patient - at least for the time being - it is paramount to introduce a culture of systematically biopsying metastases in order to gain information on the biology of the disease and, accordingly, select the best treatment option for our patients.
Data may be collected prospectively over a period of time, for a predetermined number of cases, or retrospectively from existing information sources.
This last function may be used prospectively at the design stage to accelerate the identification of σ2 receptor ligands with increased probability of selectivity over σ1 receptor.
Information may be derived prospectively in an actual case by case manner or retrospectively along case vignettes.
Moreover, such information may be used prospectively to adjust dosing and mitigate the risk of adverse events from DCA.
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