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This suggests that some but not all errors arising in the pol3-Y708A mutant strain may be proofread by the intrinsic exonuclease activity of Pol ε.
This suggests that errors arising in the pol1-Y869A mutant strain may be proofread by the intrinsic exonuclease activity of Pol ε, but not by the exonuclease activity of Pol δ.
This synergy suggests that under certain circumstances, at least some errors generated by Pol α and Pol δ may be proofread by the intrinsic exonuclease activity of Pol ε.
In the future, it will be interesting to test this hypothesis further, to determine under what circumstances, for example, translesion DNA synthesis [ 43] or base excision repair [ 44] errors made by one DNA polymerase may be proofread by an exonuclease intrinsic to a second DNA polymerase or even another protein [ 45].
Similar(56)
Single mismatches at the primer terminus can be proofread efficiently.
Although errors made by Y831A Pol ε do not appear to be proofread by Pol δ, it is possible that Pol ε might proofread errors by other polymerases.
Everything written should be proofread.
Although this excerpt has been proofread, occasional errors may appear due to the scanning process.
What little explanation there was of the book displays did not appear to have been proofread.
The manuscript was proofread and revised by all authors.
In fact, thousands of errors were discovered; in preparing our text, it was proofread three times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com