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Mitochondrial transport may be particularly essential because of the intense reliance of axons and synapses on mitochondria as a source of ATP and Ca2+-buffering.
These findings from both zTERT and hTERT rescue studies indicate that irrespective of its TR-binding ability and authentic telomerase activity, there are non-canonical functions of the RT domain of TERT which may be particularly essential for hematopoietic cell differentiation and survival.
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Negotiating a shared approach will be essential, but may be particularly difficult where these posts are held by representatives of different political parties, with differing views over how best to tackle crime.
Interestingly, all of the control organisms had at least 10-fold higher MICs and MLCs than any of the strains of H. ducreyi for each of the oils tested, suggesting that these essential oils may be particularly effective against H. ducreyi (Table 1).
This may be particularly true in carcinogenesis, where, "six essential alterations in cell physiology collectively dictate malignant growth: self-sufficiency in growth signals, insensitivity to growth-inhibitory (antigrowth) signals, evasion of programmed cell death (apoptosis), limitless replicative potential, sustained angiogenesis and tissue invasion and metastasis" (Hanahan & Weinberg, 2000).
This may be particularly important for angiogenesis where consistent inhibition could be essential for clinical benefit.
Developmental factors may also influence decisions about which parent to involve: Bögels and Siqueland (2006) suggest that as fathers may be particularly important role models for adolescents, involving them in treatment may be essential in successfully combating adolescent anxiety.
We show clear in vivo and in vitro evidence that myosin Va is in fact essential for long-term homeostasis of the mouse NMJ and that it may be particularly important for the recycling of AChR- and rapsyn-containing vesicles.
Severe epidemics may be particularly undesirable as they result in many people being sick simultaneously, which can disrupt the supply of essential goods and services.
Inasmuch as intact mitochondria are essential for the maintenance of cellular function and replication of cancer stem cells, these organelles may be particularly useful targets in cancer therapy (Deus et al., 2015).
This new status may be particularly damaging if the migrant is the mother when predominant cultural expectations about gender and caregiving prescribe maternal proximity as essential for emotional nurturance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com