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A smaller subset of CGIs that were methylated in wild-type ES cells (mean >0.8, n = 2160/21,012) showed a strong gain to 0.56 mean methylation in DKOdCas9 cat3a cells after 7 days, which may be linked to the lack of H3K4me3 (Fig. 1h, left).
This may be linked to the lack of autoreactivity of both HGN194 and 2G12 [20] (Figure S2) and/or differences in the mechanisms of neutralization.
The absence of glpO in S. diminutum and S. sabaudiense is best explained by independent losses and may be linked to the lack of pathogenicity in these two species.
We observed a downregulation of envoplakin, periplakin, and involucrin in WT papillomas and SCCs, leading us to speculate that the increased risk of SCC conversion in EPI−/− papillomas may be linked to the lack of two desmosomal proteins (Thiery and Chopin, 1999).
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They believe the clusters may be linked to the use of pesticides and described the French authorities' lack of action as a "health scandal".
Described by one respondent as they "don't usually know what to do", this problem may be linked to lack of training and lack of experiential knowledge.
Suicides are more common in rural areas than urban centres, which researchers say may be linked to a lack of economic opportunities, social isolation, and family planning policies that forced women to have abortions.
Smith and Clarke (2000) suggest that while robbery and violent offences may be linked to a lack of supervision, theft may not be.
Such adverse reactions are common [ 6, 38] and may be linked to a lack of clinical trials on humans [ 39].
Lower outlet densities in these areas may be linked to a lack of purchasing power in these communities.
Patients would appear to prefer that voluntary organisations do not provide these services, although this may be linked to lack of experience of these services.
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