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18 As EPCR plays a key role in regulating coagulation and endothelial cytoprotective and barrier properties, 19 this raises the possibility there may be linkages between IE cytoadhesion and microvascular complications in CM. 20 However, the precise molecular processes that account for the pathophysiological differences between CM1, CM2, and adult CM are poorly understood.
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Firstly, there may be linkage disequilibrium in the genetic analysis, i.e., the occurrence of certain combinations of alleles or genetic markers in a population more frequently or less frequently than these would be expected from a totally random formation of haplotypes from alleles based on their original frequencies.
Second, there may be linkage between genes regulating growth and cancer-causing genes.
It has been suggested that when using Sahara as a breeding parent, there may be linkage drag of unfavourable traits together with the 4H allele, or pleiotropic effects of the 4H tolerance allele in different backgrounds [ 26, 27].
Citation is more than a locator/identifier In the discussion of "Data independent of any paper" it is worth noting that there may often be linkages between these data and myriad papers.
The function of cytosolic glutamine synthetase 1 1 in the developing endosperm is still unclear, but there may be physiological linkages between nitrogen metabolism in aleurone cells and starch synthesis in starchy endosperm.
First, linkage disequilibrium varies between races, so PADI4_94 may be in linkage disequilibrium with the true disease-associated allele in Asian but not Caucasian populations.
While linkage equilibrium between rare variants is a very realistic assumption, rare variants may be in linkage disequilibrium with common variants.
Three endoglin-coding polymorphisms are also under investigation, as the intronic polymorphism may be in linkage disequilibrium with one of these.
Here we report that both NBS cell lines and individuals with NBS are hypersensitive to MMC, indicating that there may be functional linkage between FA and NBS.
The genetic association found in the different studies may be in linkage disequilibrium with the causative locus, thereby leading to confounding of the results.
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