APC gene may be inactivated by aberrant DNA methylation of CpG islands in their promoter regions.
Finally, genes may be inactivated or missing in rats but have an important function in another species.
Whether the cannabinoids could also be delivered in the form of an injection or in pills is less clear, the pair says, because they may be inactivated by blood serum.
These data are consistent with the idea that the spindle assembly checkpoint may be inactivated in the absence of the studied proteins.
Production and release of DILPs is induced by a circulating factor released from fatbody [19] and possibly by neuronal sNPF under certain conditions [24], [50] and may be inactivated by GABA, as shown here, and possibly by serotonin [25].
However, the different antigen choice observed in NPC patients and the finding that EBV-specific T cells may be inactivated in the tumor, possibly due to exposure to an antigenic repertoire that triggers Treg responses, suggest that the outcome of immunization strategies will be strongly dependent on the choice of antigens and antigen presenting cells.
The objective of the present study was to analyze the NOTCH2 locus either as a chromosomal translocation locus that may be altered by the 1p/19q recurrent rearrangement or as a gene that may be inactivated by a two hit process.
Antinutritional factors that are present may be inactivated.
Multiple oncogenes may be activated in a tumor, while multiple tumor-suppressor genes may be inactivated.
These may be inactivated through gene mutation, chromosomal deletion or methylation [ 25].
