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The first indication that the VTE may be dosed less frequently came from the phase II CLEAR-IT 2 study where patients required, on average, only two injections between the 12 week loading period and the 52 week termination visit.
Topical carbonic anhydrase inhibitors (CAI) are available as monotherapies or as a fixed combination with timolol maleate, a beta-blocker, and may be dosed two to three times daily.
This is typically provided in the form of the rapid insulin analogs, insulin lispro (B28Lys,B29Pro human insulin), insulin aspart (B28Asp human insulin), or insulin glulisine (B3Lys,B29Glu human insulin), which may be dosed just before the meal.
Depending on the intended use, the devices may be either stationary or mobile, and the negative pressure may be dosed in either constant or intermittent manner, usually within the range of 50 mmHg down to 150 mmHg [ 49, 50, 52].
On the other scale, a 15.1 hand horse of Stock Horse and Riding Pony build may be dosed as a Galloway.
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With the use of esmolol, significant attenuating effects were found on cardiovascular parameters in the first 5 min after stimulation; its shortening effects on seizure duration may be dose-related.
"There may be doses or types of exercise that are more effective for some people than for others".
In addition, differences in distribution patterns may be dose dependent.
In an active female population, consuming breakfast prior to exercise may improve post-exercise mood, and this effect may be dose-dependent.
Few in-vitro studies prove that TNF-α stimulates the production of HIV mRNA indicating that TNF-α may be dose and time dependent on viral replication (Vitale and Ribeiro 2007).
It has previously been well argued that such reactions may be dose dependent and indeed there are likely to be therapeutic strategies that reduce the associated risk [51].
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