Moderately differentiated PDAC demonstrated a higher expression level of DJ-1 than poorly differentiated tumor subgroup, which suggests that DJ-1 may be a differentiation related protein.
A more likely mechanism may be the differentiation of neurochemical phenotype.
We suggest that a confounding factor may be insufficient differentiation between primary, early-onset dysthymia and secondary depressions.
However, within the ESC field, it is argued that neural differentiation may be the default differentiation model of ESCs cultured without extrinsic cues to differentiate toward other lineages.
The reduced number of Nes-positive cells and decreased Nes mRNA and protein levels after the induction of differentiation may be attributed to differentiation of neural stem cells into a neural lineage.
We collected our data before 96 hours by which time early stages of differentiation, such as early neural differentiation, may be tracked, but more terminal differentiation to heart, brain, liver, kidney has not yet taken place.
The timing itself may be crucial; neural differentiation might simply need increased acetylation at an earlier time point compared to cardiac differentiation.
TRPC1 may be associated with differentiation itself; TRPC1 was required for neurite outgrowth in differentiating PC12 cells but was independent of SOCE [51].
Similarly, activity of a molt gland may be responsible for differentiation of the reproductive caste.
Thus, the withdrawal of IL-6 mediated STAT3 signaling may be necessary for differentiation to occur.
