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Treatment of the underlying malignancy may be curative if this is possible.
Such surgery may be curative for some cancers, but for others it may only relieve symptoms and prolong survival.
Bone marrow transplantation may be curative, and gene therapy has shown promise, but enzyme replacement therapy is the standard treatment.
While treatment may be curative in the early stages of the disease, the majority of patients are not diagnosed until the tumor has progressed beyond the primary site.
These therapies may serve as a bridge to liver transplantation or to endogenous liver regeneration, or in conjunction with gene therapy may be curative for congenital metabolic disorders.
Recently, the evidence has been accumulating that endoscopic resection may be curative in treating ampullary adenoma that contains high-grade intraepithelial neoplasia/in situ tumor (HGIN/Tis).
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Chemotherapy can be considered, followed if possible, by local treatment that may or may not be curative (options).
This points to the multifocal, infiltrative nature of this disease and may suggest that surgery alone may not be curative.
Liver transplantation may also be curative, but this drastic measure is reserved for the small percentage of patients who do not respond to the usual treatment or who develop liver cancer.
The latter approach is supported by long-standing evidence showing that radiotherapy may occasionally be curative when used as initial treatment for localized follicular lymphoma [10].
Leishmania infections are thus chronic, possibly lifelong, and drug treatment may not be curative.
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