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While factors explaining the high rates of reactivated TB in co-infected humans remain unclear, depletion of CD4 T cells [7] and increased virus loads [8] within granulomatous tissue may be contributors.
Hormonal variation and different recreational activities may be contributors.
There are likely multiple factors, some as yet unknown, that may be contributors [ 3].
The pathogenic potential of any individual strain can be investigated in experimental inoculation studies, but the possibility that they may be contributors to disease in mixed infections is more difficult to demonstrate.
Additionally, serrated lesions may be contributors to 15%to35%5% of cases of colorectal cancer development through the serrated polyp carcinoma pathway [ 3, 4] and to the majority of cases of interval cancer development [ 20].
Intake of sugar sweetened beverages and high fructose corn syrup [ 22, 23] may be contributors to the obesity epidemic, as the increases in consumption show a pattern consistent with the rise in obesity [ 16- 19].
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These may all be contributors.
However, differences in sensitivity and specificity of the detection methods may also be contributors.
Furthermore, differences in food handling practices and hygiene during food preparation, and amount of food consumed, may also be contributors to any apparent gender differences.
Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge through non-adaptive mechanisms.
It also reveals that both LTPA and DWPA may be important contributors to the reduced risk of premature death among this clinical population.
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