One final concern is that codons are not necessarily independent of their neighbors[ 52], or that synonymous sites may be constrained by functional demands aside from codon optimization for efficient translation.
Their range of alternatives may be constrained by wartime circumstance — more constrained than Cardona's.
In some ways, Mr. Bush may be constrained by the politics of corporate wrongdoing from offering some of the traditional Republican remedies for a bad economy and a nervous stock market, beyond those he laid out long ago.
The emergence of new infectious diseases from zoonotic sources may be constrained by at least three limiting steps.
Specialists on the human-altered habitat, in contrasts, may immediately exhibit high population growth rates upon introduction to comparable human-altered habitats in a new range, but their spread from those habitats may be constrained.
The persistence of some of these Yellow Box sites may be constrained by inbreeding once scattered trees are lost from the surrounding landscape.
However, the use of ICT tools may be constrained by their own nature: for example, the Internet user population can differ from that of telephone users (ibid).
Yet Lewandowski's hiring by CNN is striking not only because his commentary may be constrained by a nondisclosure agreement, but also given his especially abrasive dealings with journalists from various news organizations, including CNN.
"The outbreak response may be constrained by the current security situation in Côte d'Ivoire," the WHO said.
