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The proteins of interest may be cleaved from the parent protein by either chemical or enzymatic means.
Should Guardiola find himself in a similar situation, he may be cleaved in two.
Alternatively, the precursor protein may be cleaved by beta secretase, resulting in the production of a shorter soluble fragment (C99).
The analysis of bond order may predict that the weakest bonds may be cleaved preferentially, and they may possess a relatively low pi bond character.
A previous study has indicated that βNAC may be cleaved in a caspase-dependent manner during apoptosis [32], however, the functional consequences of this was not examined.
However, there is evidence that at least some of these fusion proteins may be cleaved post-translationally [80] (Majeed and Kroth, unpublished).
Similar(14)
Although CA074-Me pretreatment partially stabilized Mcl-1 and XIAP, the pretreatment also inhibited the activation of caspases, which may be cleaving Mcl-1 and XIAP on their own.
Cripto's GPI anchor may also be cleaved, releasing Cripto into the extracellular space where it may bind Nodal and signal non-cell autonomously (Yan et al., 2002; Chu et al., 2005; Watanabe et al., 2007).
Given that the doxorubicin dimer is almost water insoluble and that its azomethine bond may readily be cleaved to restore the doxorubicin monomer, the later stage of sustained drug release may involve regenerated doxorubicin in addition to the doxorubicin dimer itself[30].
Despite such filters, some of the candidates may never be cleaved by the cognate protease.
MspA (meningococcal serine protease A) is homologous to App and may also be cleaved and secreted.
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