Genomic differences common to both isolates represent the evolutionary distance between the WT and the mediator and are therefore discarded, while changes unique to the mutant are further investigated, as they may be causative.
In silico analysis predicted that this variant may be causative.
More specifically, deterioration in cholinergic basal forebrain neuronal function may be causative.
This will help avoid confusing naturally occurring sequence polymorphisms with mutations that may be causative.
Because of the unknown mode of inheritance, mutations in any of the 52 known RP genes may be causative.
Results from the latter studies indicate that there are significant race-specific differences in linkage disequilibrium (LD) between this SNP and other nearby alleles that may be causative.
Several microorganisms may be causative agents of CAP, and Streptococcus pneumoniae is the most common cause [ 1].
In many cases, cancer recurrence will clearly be the cause of death, but VTE, both evident and silent, may be causative, particularly in cases in which death occurs in the absence of obvious disease recurrence.
Inadequate pelvic collateral circulation that leads to a greater decrease in cardiac output may be causative in the syndrome.
Thus, some mutations in COL1A1 may be causative for OI and POAG.
Various physiological, benign and pathological processes may be causative for these different patterns of FDG uptake.
