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They may be autoimmune by nature or result from a T-cell-mediated suppressor effect on hemopoesis [ 6, 7].
Recent data even indicate that in some antibody-negative patients, the diabetes may be autoimmune as defined by an islet-cell-reactive T cell response 15.
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This means that, in established disease with secondary damage, at least a component of the synovitis may not be autoimmune-driven in origin.
No one knows what causes it; it may be an autoimmune disease that reacts to staphylococcus bacteria.
Etiologies may be neoplastic, autoimmune, traumatic, infectious, or unknown.
Experts aren't sure what triggers the condition (which affects about 1% of the population), but some believe it may be an autoimmune disease.
MF has an association with class II HLA DR5 and DQB*03 alleles, suggesting that it may be an autoimmune disease triggered by antigen presentation (Jackow et al, 1996).
Low-frequency antigen-specific T-cell populations have been identified in the blood of patients with coeliac disease and type 1 diabetes, and analysis of the TCR repertoire can greatly enhance understanding of the way that post-translationally modified peptides may be driving autoimmune disease processes [ 110].
Some of the remainder may have been autoimmune in nature though insufficient detail was reported to be sure (Winkelstein et al, 2003).
There appears to be substantial overlap between susceptibility variants for different autoimmune diseases, suggesting that at least part of the genetic background may be shared among autoimmune disorders.
We also ask about autoimmune disorders, as data suggests that at least some of the autistic phenotype may be induced by autoimmune mechanisms operating during pregnancy [ 37].
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