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A concomitant elimination of activated antigen-presenting cells may avoid development of antitoxin and anti-mouse Ig responses and allow repeated administration.
For example, use of mitochondrial blockers with Erlotinib, immunity blockers with Gefitinib, or combining tyrosine kinase inhibitors with antibody inhibitors, may avoid development of resistance to EGFR inhibitors.
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Early institution of renal replacement therapy may avoid the development of ARDS [ 45].
The inhibition of angiogenesis was initially proposed as a therapeutic target that may avoid the development of drug resistance.
Phosphodiesterase III inhibitors have positive inotropic, vasodilating and anti-inflamatory properties, and they may avoid the development of tolerance to catecholamines as a result of β-receptor desensitization.
At a population level, simple web-based questionnaires may inform people on their actual risk and motivate those who need to improve their lifestyle to take steps that may avoid future development of the disease.
Furthermore, antiangiogenesis approach may avoid the development of acquired drug resistance associated with conventional anticancer therapy since this approach targets genetically stable endothelial cells rather than genetically unstable tumour cells (Boehm et al, 1997).
That apparently "normal" scores are associated with subsequent development of DEB is surprising and suggests that, for early adolescent females with diabetes, particular strengths may be needed to avoid development of DEB.
With intensified treatment for these patients there may be a possibility to prevent further spread, and avoid development of a generalized incurable breast cancer.
Valve replacement must be considered to avoid development of cardiogenic shock, whereas medical treatment alone may be adequate in some cases of mitral endocarditis (3, 4 ).
A systematic approach to providing breaks in treatment schedules (intermittent chemotherapy) for patients who experience an initial response to chemotherapy may avoid or delay the development of progressive toxicity.
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