Both the π π and μ-propionato dimers of Fe(III PPIX are important species in the haem detoxification pathway in the malaria parasite and other blood-feeding organisms, and the structural insight gained in this study may assist target-driven design of new chemotherapeutic agents.
These are preliminary findings, but they may assist targeted adaptation plans in response to future rapid warming in Tibet.
We have validated the results of the primary screen through a series of secondary biological assays and find considerable overlap between the genes identified by secondary screening and the pathways identified via GSEA, indicating that pathway-centric analyses of biological screening data is a valid approach that may assist in target identification.
This information may assist in targeting efforts to improve care.
Feedback about performance may assist in targeting efforts to improve care.
For clinicians and policy makers, being armed with better evidence describing patterns of ERVH may assist in targeting and addressing those risk factors that are modifiable.
This research question is important to policymakers as it may assist in targeting interventions to certain BMI classifications, and in return maximize the use of financial resources to address obesity.
Even if the follow-up of secondary markers indicating a drug intake or a manipulation to increase the performance skills is becoming essential, direct detection of prohibited substances is still necessary to prevent athlete from cheating, and the biological passport profile may assist in targeting the doping control analysis to particular additional tests, such as GC-C-IRMS.
It is interesting that several of the proteins that interact with BRCA1 exhibit helicase/nuclease activities (e.g. the BACH1, BLM, MRE11/RAD50/NBS1 complex) and it is possible that BRCA1 may assist the targeting of these proteins to DSBs, where they play a role in break resection.
The identification of modifiable risk factors may assist in identifying targets for intervention to reduce the incidence of VRE colonisation.
Techniques such as bioimpedance analysis and relative blood volume monitoring may assist in setting targets for total volume and rate of fluid removal, although these techniques have not been widely applied in the intensive care unit (ICU) [ 11, 12].
