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With this respect, breeders may apply diverse tools, such as conventional targeted mutagenesis approaches of TILLING (targeted induced local lesions in genomes) or advanced technologies of genome editing, based on zinc finger nucleases (ZFNs), clustered regularly interspaced short palindromic repeat (CRISPR) and transcription activator-like effector nucleases (TALEN) [ 26– 28].
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Participants recommended that researchers engage in both qualitative and quantitative methodological approaches as they may apply to a given research question, and include diverse, harder-to-reach, or marginalized populations in research.
Representation from diverse ICUs and countries enhances the generalizability of these findings, which may apply to other academic trials testing currently available interventions.
Similar considerations may apply to the mixture of thyroid-disrupting chemicals analyzed by Crofton et al. (2005), where many diverse mechanisms are at play leading to reductions in circulating T4 levels.
Groups within a 20-mile radius of the arts center in Newark, and those serving people of diverse backgrounds with low incomes, will receive preference, but any tax-exempt nonprofit social service agency in New Jersey may apply.
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