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The hypothesis for samples at either 20 or at 25 km is accepted at the 1% level of significance, which may appear higher than usual but is assessed to be adequate for fitting with a function of two parameters.

The permeability measurements obtained here range between 3.5 and 6 microDarcy, which may appear higher than what is typically measured for shale cores (Tinni et al. 2012) and may correspond with a higher permeability zone.

However, the pattern of tearing is variable; in some instances the slits may appear higher up on the peridium, in others the peridium rips more irregularly.

An important note, regards the relatively high percentage of Arc+ new cells reported here, which may appear higher than those seen by some [32], [33].

Here we are concerned with the other end of the range and show the opposite effect: due to a backward bifurcation, the values of R0 estimated directly in mesoendemic scenarios may appear higher than the number of secondary infections that would be generated by the introduction of a single infectious person into an otherwise naïve population.

This estimate may appear high, which makes our power calculation rather conservative.

Although K d may appear high it would be expected to affect [Ca 2+ ] due to its very high concentration.

Although Kd may appear high it would be expected to affect [Ca2+] due to its very high concentration.

The mortality in the first period may appear high compared with that in some studies published at the same time [ 26, 27].

In our study population, seven out of 20 tumours (35%, 95% CI 12 58%) had oligodendrial features, whose proportion may appear high.