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In the case of small countries, assistance with data collection and analysis may always be required.
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Our study was successful in showing that a 4.5-mm locked proximal tibial plate may not always be required for treatment of tibia plateau Schatzker V and VI fractures when a simple fracture pattern exists in non-osteopenic bone that would allow true load-sharing between the implant and the bone.
Among possibilities to explain ubiquitin ligase independent effect of RNF5 is that RNF5 may impair muscle function by squelching or recruiting components of the ER machinery, by outcompeting its associated ligases (i.e. CHIP or gp78), or by acting as an E4 ligase on specific substrates after their ubiquitination by another E3 for which ligase activity may not always be required (i.e. p300 [44]).
In contrast, the Mexican guidelines state that in vitro studies may not always be required.
Intriguingly, no homolog of XRCC4 has been found in S. pombe, raising the possibility that such a factor may not always be required for classical NHEJ.
In some specific subsets of very early-stage adenocarcinoma, especially pure GGO lesions, systematic lymph-node dissection may not always be required [74].
The choice of a multi-faceted approach was likely to be important given that identified barriers existed at multiple levels, although such an approach may not always be required for guideline implementation [ 30].
27 Although PK/PD modeling examples of intervals other than QT are limited, it appears most other endpoints are typically treated similar to QT, although heart rate correction may not always be required for other ECG intervals.
As such, a comprehensive exposure assessment study may not always be required if there are existing factors that link pesticide concentrations together with activity patterns and exposure factors to potential exposure.
The lack of a detectable XRCC4 ortholog in S. pombe has led to the proposition that such a factor may not always be required for classical NHEJ (Hentges et al. 2006; Wilson 2007; Cavero et al. 2007).
Since inhibition of many kinases may thus not always be required for significant clinical activity in imatinib-resistant GIST, it may be possible to develop well tolerated and yet effective inhibitors for imatinib-resistant GIST.
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