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The addition of these four nucleotides may alter specificity, resulting in amplification of the greater numbers of distinct trap haplotypes observed in both birds.
Mutations introduced for the purpose of increasing the solubility of the expressed protein may alter specificity determining elements of the mutated protein domain.
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A specific mutation in the variable heavy and/or light chain regions of an anti-EBNA-1 antibody may alter its specificity from one that only recognizes EBNA-1 to one that recognizes EBNA-1 as well as dsDNA.
Hartman et al. also suggested that a novel mechanism may alter the specificity of STAT1 binding, depending on whether it is induced by IFN-α or IFN-γ.
In order to test the possibility that removal of this conserved sequence may alter tissue specificity of the NDUFV1 upstream region, we have PCR-amplified and cloned two genomic fragments, one including the whole, 3665 bp-long upstream sequence, and the other, 3574 bp-long sequence lacking the conserved region.
Genetic variants of Cox-2 with nonsynonymous single-nucleotide polymorphisms (SNPs) in the coding region may have altered specificity, function, and/or interaction with NSAIDs, and may contribute to colorectal cancer risk.
However, changes in domain partners can also alter specificity.
Changes in the C-terminal domain of ADAMTS4 may alter its substrate specificity.
An AA substitution found in MoeBRs and MoeZs may alter the substrate specificity of these enzymes.
However, whether such a mutation may alter receptor binding specificity in the pandemic (H1N1) 2009 virus is unknown.
This polymorphism, which leads to a substitution of glutamic acid for a basic lysine (E713K) that may alter substrate-binding specificity [ 18], likely modulates the function and expression of DRD2 due to its close proximity [ 19].
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