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The methods we have established in this work will facilitate future investigation of how circadian coordination modulates xenobiotic metabolism, and how genetic or environmental perturbation of the clock may alter responses to chemical exposure.
Pharmacokinetic differences in the fetus, newborns and children may alter responses to environmental chemicals compared to adults, potentially resulting in a different spectrum of susceptibility to adverse health effects.
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Additionally, there is evidence to suggest that the total number of ovarian follicles may alter response to hormonal synchronization protocols.
Although our data does not exclude the involvement of multiple mechanisms it suggests that DcR3 may alter response to platinum at least in part by regulating the expression of BRCA1.
A new laboratory study documents different responses to air pollution in stressed and nonstressed rats, supporting the epidemiologic evidence that chronic stress may alter respiratory responses to air pollution [ EHP 118 769 775; Clougherty et al.].
Knowledge of how landscape position and nutrition influence white ash health may alter management responses to insect outbreak events.
Astrocyte-specific inhibition of NF-κB activation has been shown to dramatically ameliorate immune infiltration and tissue damage in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, suggesting that genetic modulation of NF-κB signaling may alter astrocyte responses and astrocyte-mediated MS lesion pathology9,10.
In this study, we evaluated whether the URB937 administration may alter nociceptive responses in an animal model of migraine based on nitroglycerin (NTG -induced hyperalgesia [2].
Such allostatic load, in turn, may alter brain responses to stressors; therefore, behavior and systemic physiology are altered in ways that can, in a vicious cycle, lead to further allostatic load [7].
Moreover, statins may alter inflammatory responses in humans.
Furthermore, experiences of threat by peers may alter cognitive responses to threatening situations.
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