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However, invasive techniques may alter normal physiological function, thus generating a modality-based impact on vessel's permeability, which needs to be corrected for.
Similarly, naturally occurring defects such as osteochondrosis lesions may alter normal contact mechanics in affected joints.
The change in the steroid metabolism profile in vitro suggests that maternal drug abuse may alter normal hormonal homeostasis during pregnancy.
Environmental chemicals such as phenols, phthalates, and dioxin-like compounds are endocrine disruptors that show estrogen-like activity and may alter normal brain development (Tanida et al. 2009).
There is general concern that persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues, and fluids may alter normal human physiologic activities (e.g., fetal development, immune and endocrine systems).
How this affects the function of PAB6 is presently unknown, but the ability to bind poly(A) RNA while unable to interact with PAM2 motif-containing proteins may alter normal PABP function substantially.
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Loss of IDH function may also alter normal mitochondrial function and promote a metabolic switch in cancer cells to glycolysis.
Individuals with spondylolysis, lumbosacral transition levels, and prior spine surgery were excluded in order to eliminate the contributions of these factors, which may alter 'normal' spine biomechanics.
Traumatized veins may suffer partial or complete disruption, intimal injury, or post-traumatic thrombosis and this may alter the normal characteristics of these vessels.
Atherosclerosis of the VA and degenerative changes in the cervical spine are likely to occur with aging, and subsequent morphologic changes may alter the normal anatomy.
These mutations may alter the normal function/transport of TDP-43 or they may cause a toxic gain of function of the protein by altering its C-terminal [19].
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