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Hepatic dysfunction may alter multiple critical coagulation factors which are produced by the liver, which may explain some of the coagulation abnormalities associated with HIV infection.
However, viewing dioxin and related compounds as endocrine disruptors that may alter multiple pathways sheds some light on the complexities of this potent class of growth dysregulators.
Thus, zinc is an essential micronutrient for healthy functioning of the human body and moderate to severe deficiency of zinc may alter multiple physiological and metabolic functions.
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Moreover, it offers a methodology for evaluating how climate changes due to human activities on the land may alter the multiple services offered by ecosystems to human beings.
As all forms of female mate choice can significantly impact the strength and direction of sexual selection, any variation based on female age or experience may have important evolutionary implications that may alter selection for multiple male sexual traits [8], [14].
Dysregulated adipose tissue may alter glucose metabolism by multiple pathways that include subclinical inflammation (37) and lipotoxicity (19– 219.
These protein cascades provide sufficient flexibility and redundancy that mutations in these regulatory pathways may alter the expression of multiple enzyme systems.
The respiratory disturbances in OSA are typically associated with intermittent hypoxia and transient arousals, which may alter glucose metabolism through multiple pathways including activation of the sympathetic nervous system, dysregulation of the hypothalamic-pituitary axis, and systemic inflammation (24– 24).
This event may alter a single gene or multiple independent events may target a coordinated program of genes.
Identical unique loci were affected in patients presenting distinct genital phenotypic traits, which suggest that structural perturbations within these segments may alter master regulator(s) of multiple processes of human sexual development.
Each individually related gene in multiple pathways may alter the risk for prostate cancer, and might contribute only modest risk.
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