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An alternate model is that the LB1-induced increase in nuclear rigidity may alter cells' nuclear signaling (for a review, see refs. 50, 51).
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Measurements in live, unprocessed specimens are clearly preferable for estimates of concentration likely to be affected by sample processing procedures that may alter cell volumes differently in cells with normal and altered permeabilities.
Since individual splicing choices may alter cell fate determination, axon guidance, and synaptogenesis, these findings suggest the retrieval of balanced splicing as a goal for DS therapeutic manipulations early in DS development.
The possibility exists that the phosphorylation status of Id2 may alter cell cycle progression by regulating cyclin A expression.
Lack of pendrin expression leads to epithelial cell stretching and luminal acidification, which may alter cell signaling to result in the observed retarded development of stria vascularis.
However, we cannot exclude the possibility of long lasting effects of hormones that may alter cell development and thus gene expression profiles.
Stretching and luminal acidification may alter cell-to-cell communication and lead to the observed retarded development of stria vascularis, which may be an important step on the path to deafness in Slc26a4−/− mice, and possibly in humans, lacking functional pendrin expression.
Aging may alter cell activity, but likely also alters the biochemical environment [ 40].
Our data suggest that vorinostat may alter cell morphology and invasiveness through an ALDH1-associated pathway.
This may alter cell signaling in the steady state and modulate the cell machinery that regulates cell survival or proliferation, thereby resulting in suppressed cell proliferation.
The lipopolysaccharide or poly-γ-glutamate biosynthesis proteins may alter cell surface characteristics, contributing to host recognition of the frankial cell envelope.
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