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However, there is evidence that genetic alteration between the primary tumour and CTCs may alter both prognosis and therapy options; for example, a Her-2-negative primary breast cancer based on immunohistochemistry and fluorescence in situ hybridisation may in fact release CTCs that are positive for Her-2 [ 69].
Explain that they may alter both interior and exterior walls, as long as the original building is still recognizable.
Chronic pain may alter both affect- and value-related behaviors, which represents a potentially treatable aspect of chronic pain experience.
These findings suggest that the presence of a tumor may alter both local and more distant structural connections.
The most common types of rapid change are those associated with the impact of large waves, be they storm surges or tsunamis, that may alter both the position and nature of the shoreline.
This is particularly important when IAPs are considered transformers (or drivers of ecological change) because they may alter both subtle and obvious components of ecosystem functions and services, e.g. by being excessive users of nutrients, donors of limiting nutrients, fire promoters/suppressors or salt accumulators/redistributors (Richardson et al. 2000; Richardson and Gaertner 2013).
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Studies have reported that prenatal exposure to polychlorinated biphenyls (PCBs) may alter neurodevelopment in both humans and animals.
This may alter their immune response both in vitro and in vivo.
Co-infection with HIV and hepatitis C virus may alter the course of both infections and may have contributed to the severity of this patient's illness (4 ).
Furthermore, nanoparticulate SWNT WT1Pep427 conjugates may alter trafficking and clearance both intracellularly and at the tissue level in vivo, such as providing a depot effect.
The 5-HT2AR the2C and the A-1438 G polymorphism are silent mutations, but both may alter promoter activity and expression of 5-HT2ARs (30,31).
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