Sentence examples for may alter binding from inspiring English sources
Protein modeling demonstrated that the missense mutation is damaging and may alter binding to ATP molecules.
Therefore, V370A may alter binding affinity with the death domain of EDARADD and thereby influence the activation of NF-κB.
We used ITC to assess how these effects may alter binding.
Variants in the αMβ2 ligand-binding domain may alter binding affinity, hence leukocyte trafficking, phagocytosis [ 16], and IC clearing [ 19].
As these residues are located in or near the hydrophobic groove, their phosphorylation may alter binding and/or activation by BH3-only proteins.
Thus, it is tempting to speculate that EGFR variant may alter binding of its specific ligands leading to a particular phenotype of EGFR signaling.
Our results, when combined with those of others [ 10, 6], imply that the methylation level at the 12th position of CTCF binding sequence may alter the binding environment, resulting in different zinc-finger binding and, in turn, recruiting different cofactors that ultimately leads to divergent functionalities.
The intrinsic stability of mRNA is determined by cis-acting sequences located within the 3′ UTR as well as trans-acting RNA-binding proteins (25); 3′ UTR variants may alter the binding of these proteins or alter the secondary structure of the 3′ UTR.
A fourth mAb with a longer CDR2 loop was not affected by mutation of residue 57, indicating that CDR2 domain length may alter the binding interface and lead to the involvement of other residues in protein A binding.
Importantly, our results demonstrate that H547A-hDAT displays increased Km value for DA uptake relative to WT hDAT, indicating that mutating the His547 residue may alter the binding site of substrate DA.
The relative binding strength of H to the two surfaces, inferred via tip-induced diffusion barriers, suggests that the strain in these systems may alter adsorbate binding and corroborates well-known trends in d-band shifts calculated by the density functional theory.
