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These results suggest that although Bmi-1 contains no known p38 phosphorylation motif (http://www.scansite.edu), p38 may also phosphorylate Bmi-1 when Akt is unable to phosphorylate Bmi-1 under oxidative stress conditions.
ERK1/2 may also phosphorylate ribosomal S6 kinase (S6K), which leads to the phosphorylation of cyclic adenosine monophosphate response element binding protein, eventually affecting the regulation of the expression of NGF-inducible genes and, thus, contributing to neuronal differentiation or neurite outgrowth [ 50].
Upon RNA interference against JIL-1 the fraction of phosphorylated SU VAR 3 9 dropped to 27% suggesting that although JIL-1 is a major kinase for this site other kinases may also phosphorylate the N-terminus of SU VAR 3 9.
CDC7 may also phosphorylate claspin and activate ATR-CHK1 checkpoint pathway.
Other kinases, like Plk-3, homeodomain interacting protein kinase 2 (HIPK-2), may also phosphorylate p53 giving apoptotic outcomes [ 71].
PKC may also phosphorylate the BH3-only protein Bad which increases the availability of Bcl-2 for antioxidant and anti-apoptotic functions.
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Mst1/2 can also phosphorylate Mob1, which may further promote pathway activation through a currently undefined mechanism.
Pheromone-activated Fus3 and Kss1 also phosphorylate the same Ste50 residues, suggesting that Ste50 phosphorylation may also serve as a cross-regulatory mechanism between the mating and HOG pathways (Yamamoto et al. 2010).
Other kinases can also phosphorylate P450c17, but only p38α has been shown to affect its enzymology.
In vitro-purified PKC can also phosphorylate IR and lower its tyrosine kinase activity (Bollag et al., 1986).
JNK can also phosphorylate and inactivate MCL-1 [49], [49].
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