Sentence examples for may also inactivate from inspiring English sources

Thus, it is highly possible that hypoxia may also inactivate VHL function as a tumor suppressor besides stabilizing HIFα by blocking hydroxylation.

Other mechanisms, such as DNA sequence mutations or methylation, may also inactivate these tumor suppressor genes.

There is some evidence that the forced expression of PPAR-γ, C/EBP-α, or albumin may also inactivate PSC.

Homocysteine thiolactone may also inactivate enzymes responsible for posttranslational modification of connective tissue matrices leading to fibrosis and scarring [ 56].

As AGAT removes methyl adducts from DNA via a suicide mechanism, it has also been suggested that protracted exposure to an alkylating agent may not only saturate AGAT copies available within cancer cells, but may also inactivate the new molecules while they are being synthesised, thus leading to AGAT 'depletion' and overcoming the inherent resistance of glioma cells.

The same argument applies to merotelic states (class 4), the probability of which increases when the q/ p ratio is small (Fig. 2 d, g); stabilisation of kMTs (Fig. 3 b and Additional file 1: Figure S7B) may also inactivate the spindle assembly checkpoint in merotelic states over time.

JNK may also be inactivated by IKK β.

However, LKB1 may also be inactivated in sporadic pancreatic cancer [ 33].

The PI3K/AKT/mTOR signalling pathway is under the control of PTEN, but it may also be inactivated by a feedback loop in which S6K1 directly inhibits IRS1.

Even so, in the periphery, the expressed light chain may also be inactivated by somatic mutation, and an autoreactive light chain can be re-expressed [ 91].

Although TP53 mutations are not so frequent in sarcomas [ 41], the pathway may also be inactivated by amplification of the MDM2 gene [ 2, 5, 18] which is observed almost exclusively in tumours where TP53 is wild-type.