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For example, scavenger receptor-mediated endocytosis may allow uptake by specific Drosophila cells [ 56, 57].
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Simultaneously, increased expression of the pctABCD operon coding for an ABC transporter with yet unknown substrate specificity may allow the uptake of phosphorus-containing compounds.
The transporters included those from all seven major transporter categories, which may allow the uptake of essential nutrients or ions, and extrusion of metabolic end products and hazardous substances.
Our observation of greater expression of sPLA2 and Msr1 in the spleen of CVB3 infected males may allow oxidation and uptake of LDL-cholesterol and activation of TSPO for the production of steroids in splenic macrophages.
Regardless of putative proteins that may allow increased fatty acid uptake, unesterified fatty acids also cross cell membranes in their protonated and therefore lipophilic form by the so called flip-flop mechanism [21].
Alternatively, mobile antigens that can be concentrated into small clusters on the target cell membrane may allow for clathrin-mediated uptake processes similar to those involved in endocytosis of soluble immune complexes.
Recent evidence suggests that there are FAT/CD36 transporters on the mitochondrial membrane [25] [26] and although sex differences in the mitochondria specific population have not been examined, women have significantly greater FAT/CD36 protein in whole muscle homogenate compared with men [18], which may allow for greater mitochondrial uptake of long chain fatty acids (LCFAs) in women.
However, because 177Lu can only be imaged using SPECT cameras, a PET equivalent such as 89Zr-labelled I253A/H310A might be a better alternative and may allow better quantification of tumour uptake and saturability in vivo.
The combined approach impressively boosted tumour uptake and may allow clinical application of potent internalizing peptide receptor agonists without bioactivity concerns.
Slow absorption of brevetoxin that occurs with an inhalation exposure compared with rapid uptake of a bolus dose may allow brevetoxin metabolism to less neurotoxic metabolites to occur, or allow time for uptake into tissue sinks such as skeletal muscle.
The capacity for AuNPs to be uptaken by cells may allow improved delivery of antigens and therefore improve the overall vaccine antigen dose delivered to APCs.
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