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The use of low affinity anti-viral drugs interfering with HIV-1 coreceptor interaction may allow targeting multiple cellular coreceptors while maintaining the ability to inhibit interactions of a viral glycoprotein, which is subject to frequent mutation.
Finally, since appending proper target sequences to luciferase may allow targeting to specific regions of the plasma membrane, we anticipate that pmeLUC may even allow to probe changes in the extracellular ATP concentration at restricted sites of cell-to-cell interaction.
Identification of risk factors underlying fatal outcome in bacteraemia may allow targeting of preventive efforts to individuals likely to derive greatest potential benefit.
Combinations of interventions should be considered as they may allow targeting different components of disease, thus lowering side effects while increasing efficacy.
Since HSP70 expression on tumor cells is a prerequisite for natural killer (NK) cell-mediated tumor lysis, we hypothesized that CD99-induced HSP70 may allow targeting of some CD99-positive malignancies via NK-cell cytotoxicity.
As an example, consider a nanoparticle carrying a payload of an active drug and having at its surface moieties that allow stealth features, such as PEG and moieties that may allow targeting including peptides, nucleic acids, proteins, or antibody fragments that bind certain receptors.
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Current technology allows gene expression to be down-regulated using antisense or co-suppression and future developments may allow targeted gene mutation or gene replacement.
Pathophysiological information from CT or MRI increasingly helps clinical trial design, may allow targeted therapy in individual patients, and may extend the time scale for reperfusion therapy.
Identification of children who do not prefer active play and who have motor problems may allow targeted interventions to support their motor learning and participation in active play and thereby promote their physical activity and fitness in later life.
Distinguishing these infants may allow targeted interventions early in life to optimize adult health.
The far-red spectrum of mRFP1 and the PSmOrange [ 52] which have a greater tissue penetration may allow targeted use in in vivo imaging in small animals [ 54].
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