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In conclusion, although detachment of adhered MSC on culture dishes via exposure to cold may allow structurally and functionally intact detached cells, the technique requires improvement of the thermotolerance of MSC.
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The advantage of this approach is that the introduced chemical handle is smaller than a conventional label, and therefore, may allow crosslinking to structurally less accessible amine-acceptor glutamine residues as well.
Finally, while intein-based trans-splicing may allow reconstitution of a desired split-protein with fully preserved structure, the protein stapling evidently permits combinations of structurally unrelated proteins and thus could be suitable for production of multienzyme complexes, antibody enzyme conjugates, heterofunctional targeting agents for binding two receptors, and so forth.
However, their differing genetic potentials for biosynthesis of cofactors and amino acid precursors may allow the coexisting AMD plasmas to take advantage of microniches that occur in structurally differentiated biofilms [ 87].
In contrast, STX140, STX243, 2-MeOE2, ENMD1198 and colchicine are structurally different to paclitaxel; they bind to the colchicine site and they have a conformation, which may allow the formation of a stable complex with class III β-tubulin.
This may allow Softbank a dignified exit.
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This may allow prolonged battery life.
This may allow bacteria to grow.
Some forums may allow very large avatars.
These structurally diverse extracellular miRNA-containing entities may also allow target enrichment and therefore improve the utility of miRNAs as biomarkers.
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