Sentence examples for may allow methylation from inspiring English sources
Interestingly, at multiple smoking-associated sites DNA methylation levels of former smokers are generally similar to levels observed in non-smokers, which suggests that smoking cessation may allow methylation levels to revert back.
These are CG-rich foci in the sequence that allow methylation of the promoter DNA, which may result in silencing of the gene.
One hypothesis is that PHD3 silencing by promoter methylation may allow for an increased HIF transcriptional response during hypoxic conditions.
However, reduction of PHD3 expression by DNA methylation may allow for stable HIF directed cellular response during hypoxia [ 12].
It can be postulated that this form of XCI, which starts with the remodelling of the future inactive X by chromatin modifications, but does not include Xist DNA methylation may allow for a more dynamic X-linked gene silencing at these early stages.
The ability of TALEs to target methylations may allow introducing modifications on the DNA level.
The use of epigenetics to identify a role for methylation in keloids may allow for a better understanding of keloid pathogenesis and could lead us closer to scarless surgery.
An expansion of this concept (i.e., that gene-specific methylation is altered by environment) to epigenomics may allow investigators to determine whether signature patterns of DNA methylation occur across the WBC epigenome that are specific to exposure to certain types of chemicals.
Integrated analysis of DNA methylation and gene expression may allow for the identification of new therapeutic targets and/or biomarkers prognostic of disease response.
This may allow us to better use the available methylation and histone deacetylase (HDAC) inhibitors based on the underlying genetic abnormalities that have shown some clinical success in the treatment of myeloid leukemias [ 77, 84].
Therefore, the integration of such data as variables may allow us to identify composite effects between methylation characteristics and genomic alterations that can influence the expression change of pathways and point to novel, previously unknown regulation mechanisms.
