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However, recent interest in shrinking the treatment volume to involved node radiotherapy (INRT) may allow lower doses to critical organ structures.
This chemosensitisation may allow lower concentrations of gemcitabine to be used, thereby reducing the risk of toxicity or increasing the available efficacy at standard gemcitabine doses.
The use of criteria based on lung function studies to determine diagnosis may allow lower levels of antigen exposure.
Most immediately, the AZM synergy with colistin we demonstrate here may allow lower dose, colistin-sparing regimens that reduce adverse drug effects.
26 Further, some new technologies may allow lower unit costs (ie, treatment becomes cheaper) or cause less discomfort or complications, thereby offering the potential for cost savings.
Inactivation of SIK3 may allow lower doses of antimitotic drugs to be used, and thus may benefit patients by lowering the side effects of the drugs.
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Other innovations may have no measurable effect on quality but will reduce costs; for instance, new technologies may allow lower-skilled workers to substitute for some of the tasks highly paid clinicians now do.
Providing mineral sources that are more available to the animal may allow for lower supplemental inclusion rates to the diet.
Therefore, the development of combinatory therapies that profit from the ACSL4, lipooxygenase and COX-2 synergistic action may allow for lower medication doses and avoidance of side effects.
Furthermore, this work indicates that the addition of 2DG to a chemotherapeutic regime may allow for lower doses of chemotherapy to be used, thereby reducing chemotherapy-related toxicity.
This could prove to be very advantageous since it may allow for lower doses of NSAIDs to be used, thereby limiting the adverse effects associated with long term NSAID use.
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