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Besides its role in immune evasion [ 54], LPS sialylation may allow interaction with SIGLECs (sialic acid-binding, immunoglobulin-like lectins) located on myeloid cells [ 55].
The phosphorylated receptor binds, with high affinity, a member of the arrestin family (ENSFM00250000000572), which prevents further signalling through the G protein (uncoupling) and may allow interaction with scaffolding proteins, such as clathrin, with the possible consequence of internalization and/or degradation.
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Likewise, the unique C terminal domain of RBf2 may allow interactions with different types of regulators.
A lecture, for example, could involve contact with a member of staff instructing a large group of students, while a seminar or tutorial may allow closer interaction between students and a lecturer.
We regard it possible that such a dynamic ATP-dependent conformatransitionnsition may allow transient interaction(s) during the excision reaction that ultimately positions a displaced ssDNA strand in the MutL cavity [13].
This may allow efficient interaction between the hydrophobic lid residues with the lipid interface and contribute to easier lid opening.
These differences may allow the interaction of EphB2 with a different range of substrates and could account for the recombinant expression profile that we have observed.
This might be due to its N-terminal polyarginine domain, which may allow its interaction with negatively charged phosphate moieties in the cell membranes, which is suggestive of a cell-penetrating domain [ 55].
The intracellular compartments and events that may allow this interaction to occur in human endothelial and epithelial cells as well as the downstream consequences are the subjects of current investigations.
Moreover, these findings are supported by focus group results, which indicate that the high IT sophistication home had more robust and integrated communication strategies (both IT and non IT) that may allow for interactions throughout the facility and require less frequent face to face interactions between CNAs and RNs or LPNs to verify orders or report patient status.
F181 (at a distance of 3.9 Å), L185 (distance of 3.6 Å), and also F89 (distance of 3.4 Å) may allow hydrophobic interactions with the ligand.
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