Purifying selection works on the function of exons' final protein products and may not allow frequent recombination between sequential series of coding sequences, which leads to strong LD in these sequences.
Canakinumab, a fully human interleukin-1β monoclonal antibody, approved for the cryoporin-associated periodic syndrome, may offer a practical advantage because its half-life of ∼28 days may allow less frequent dosing.
This observation requires further evaluation and may allow more frequent use of AIs in males, possibly in combination with a gonadotrophin-releasing hormone agonist.
Other doctors may allow more frequent ear infections before intervention.
As a result, Maxwell may only see a few starts each week when he slumps, making him a more viable power specialist in leagues that allow frequent (daily) lineup adjustments.
Single exon gene variants, usually the product of a retrotransposition event, are smaller than their multi-exon counterparts which may allow for more frequent and higher fidelity duplication.
Authors hypothesize that this approach may allow identification of frequent and consistent epistatic effects at the expense of lower test power, improving the filtering of false positive results at the expense of increasing false negative rate.
The structure of albiglutide provides an extended half-life (∼5 days), which may allow weekly or less frequent dosing.
Indeed, many concurrent factors, such as the contamination of foods with long shelf lives, the long incubation period, and infrequent infections vs. presumably frequent exposures, may allow a listeriosis outbreak to occur as a succession of apparently unrelated cases [ 25].
Excessive or improper brushing and combing can pull hair out prematurely, preventing quick and natural gains in hair length that gentler or less frequent brushing may allow.
