Importantly, non-linear techniques may allow estimation of more complex effects such as coupling across frequencies [39] and gain control or gating [54].
Similarly, toxicity data may allow estimation of probabilistic risk for some stressors, while providing only qualitative descriptions for others.
When differences in IGE originate from factors that usually go together with relatedness such as familiarity, rather than from relatedness per se, experimental designs that disconnect relatedness from those factors may allow estimation of the full set of genetic parameters.
Finally we discuss the consequences of analysing data in which IGEs depend on relatedness using a traditional IGE model, and investigate group structures that may allow estimation of the full set of genetic parameters when IGEs depend on kin.
In addition, as an outcome measure, imaging may allow estimation of the change of these variables during urate-lowering therapy; that is, as MSU crystals dissolute due to the long-term effect of subsaturating serum urate levels achieved during urate-lowering therapy [ 2].
Identification and enumeration of CTC at or before the diagnosis of the primary tumor may allow estimation of the probability of DM being present and thus help identify patients who will benefit from more intensive adjuvant therapy after surgical removal of the primary lesion.
