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Studies performed by using microarrays for each bacterial species, one by one, with a large number of targets, testing different physiological conditions may allow defining optimal targets for this purpose.
In addition, studying patterns of different phosphorylated signaling molecules in patients with or without clinical response may allow defining if clinical benefit is guided by a different modulation of the immune system by CTLA4 blocking antibodies.
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Relating clinical and molecular differences may allow us to define more specific subtypes of patients that respond differently to therapeutic interventions.
It may allow us to define changes in expression of genes of particular pathophysiologic or therapeutic interest, which in turn may lead to more appropriate therapeutic interventions for patients.
The study of how mechanical forces may influence cell behavior via cytoskeleton remodeling is a relevant challenge of nowadays that may allow us to define the relationship between mechanics and biochemistry and to address the larger problem of biological complexity.
We suggest that assessing the comorbidity status in MM, rather than considering specific age cutoffs alone, may allow to better define patients' status, tolerability of treatment and to learn about best treatment allocations in upcoming patient cohorts.
President Obama's statement suggests he may allow Secretary Leon Panetta to define "long-term" so narrowly as to exclude almost anyone the U.S. detains in Afghanistan, either now or in the future.
The combination of theoretical and experimental approaches may allow us to better define this curve and provide new insights into the normal function of the mesofrontal DA system as well as its possible dysfunction in the pathophysiology of schizophrenia, chronic stress, or drug addiction.
PHI may allow prioritization for population groups defined by region, age, race/ethnicity, or sex group as well as identify specific indicator, disease or factor weighing on the ranking of the index.
Further study will be required to define conditions that may allow resolution of these additional linkage isomers either.
Comparing the in vivo studies with defined in vitro studies may allow deconstruction of the stimuli acting in the in vivo microenvironment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com