Especially during severe illness, the expression of insulin-independent glucose transporters on the membranes of several cell types is upregulated, which may allow high circulating glucose concentrations to overload and damage these cells [ 4– 7].
During severe illness, the expression of glucose transporters on the membranes of several cell types is upregulated, which during reperfusion after ischemia may allow high circulating glucose levels to overload and damage these cells.
Wire shelving may allow air to circulate, but do you really want to store your cashmere sweaters on an oven rack?
These results suggest to industry that the death toll from a cohort may not be the best indicator for MDV prevalence in the flock and reliance of observing mortality may allow MDV to circulate freely in the broiler population.
In the future, liquid biopsies of circulating plasma DNA may allow for a less invasive approach to assessing biomarkers in mCRC patients: mutations detected in circulating plasma DNA show good concordance with tumour mutations, particularly when samples are paired [ 68– 70].
Moreover, populations with very low immunity may allow OPV viruses to continue to circulate and eventually evolve to become circulating vaccine-derived polioviruses (cVDPVs) with properties similar to WPVs.
If confirmed in larger prospective studies, regular monitoring of patients with primary breast cancer by an optimal combination of circulating biochemical markers may allow detecting individuals with bone metastases at an early stage, potentially before detection with bone scintigraphy.
New tumour-sampling techniques, CTC collection or the analysis of circulating tumour DNA, may allow a more comprehensive analysis of the clonal composition of a cancer provided that cancer cells are shed into the circulation proportional to their clonal frequency.
Quantification of potential surrogates of tumour cell burden in the body, such as circulating tumour cells and circulating nucleic acids and proteins, may allow identification of alternative signatures guiding the further clinical development of individualised vaccines.
Data from spotted hyena showed that the reduced expression of placenta aromatase may allow the hyena placenta to convert high circulating concentrations of androstenedione to testosterone, and could explain the virilization of the fetal external genitalia in female fetuses [ 103].
