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The possible synergistic effects of genotype and smoking may aggravate oxidative stress and contribute to the development of diabetic nephropathy.
These findings demonstrate that the loss of Zfp637 may aggravate oxidative stress-induced premature senescence because of increased susceptibility to ROS.
We infer that cellular PHLPP2 levels may aggravate oxidative toxicity by suppressing Nrf2/ARE transcriptional regulation via Akt(Se473)/GSK3 β/Fyn kinase axis.
Damage incurred may present itself as apoptosis, lipid peroxidation, DNA degradation, protein modification, inflammation and ultimately cellular death [ 3], which may aggravate oxidative stress-related disorders [ 4].
The possible synergistic effects between the genotype and smoking implied that a positive interaction between genetic and nongenetic factors may aggravate oxidative stress and contribute to the development of diabetic nephropathy in Chinese type 2 diabetic patients.
Similar(55)
This indicated that endogenous pro-oxidant system was triggered under diabetic condition which may further aggravate oxidative stress.
On the other hand, we do not exclude the possibility that high dose of OPLE, depending on the duration of treatment, may perhaps aggravate oxidative stress in our animal model of DN.
Less intake of antioxidants may aggravate arsenic-induced oxidative stress.
The amplified oxidative stress in patients with type II diabetes and chronic nitrate therapy may aggravate the harmful vascular effects, and contribute to an increased adverse long-term clinical outcome.
Increased responsibilities may aggravate the problems.
The reaction from markets may aggravate the situation.
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