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Exact(11)
The N-terminal region may affect substrate processivity.
Conserved sites are potentially important for the structural conformation of these proteins, whilst differences may affect substrate preferences.
The A119S substitution is located in substrate recognition site one (SRS1) (Gotoh, 1992), and may affect substrate binding.
This, accompanied by mutations at residue 67, may affect substrate selectivity of the enzyme preventing incorporation of drug-triphopsphates.
Among all putative promoter variations, there were 4 sites which may affect substrate utilization in EA 2018 (Table 3).
The differential subcellular localization of SIRT1 in normal and cancer cells may affect substrate accessibility and partially account for the contrasting roles of SIRT1 in tumorigenesis.
Similar(49)
Since this SNP may potentially affect substrate specificity, it may be functionally important in certain populations.
Presumably, the presence of additional regulatory domains may also affect substrate preference, as interactions may also change.
Flogel et al. [ 53] propose that decreased myoglobin may directly affect substrate selection.
However, binding of the inhibitor may also indirectly affect substrate binding; this notion is supported in part by the observation of mixed mode inhibition kinetics when 5-carboxy-8HQ was tested with varying concentrations of 2OG (Figure S2).
Physically, NIS may affect the substrate itself, or alter habitat architecture, indirectly influencing water movements, sediment accumulation, and light conditions.
More suggestions(15)
may be substrate
may affect vulnerable
may include substrate
may guide substrate
may modify substrate
may protect substrate
may enhance substrate
may trigger substrate
may share substrate
may reduce substrate
may help substrate
may affect clinical
may decrease substrate
may inhibit substrate
may perturb substrate
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