[GISTIC takes this approach, although Beroukhim et al. (2007) make no mention of probe bias.] In the Supplementary Material, we discuss simulations that show that probe bias may still affect segmented data.
The disease may be localized to a segment or may affect longer segments of bowel [ 13].
Mural thickening is circumferential in the majority of cases and may affect any segment of the large bowel.
CD is an inflammatory bowel disease affecting both adults and children characterized by a chronic clinical course, with exacerbations and remissions, and by a trans-mural inflammation that may affect different segments of the digestive tract.
Since divergence in disordered segments may affect protein half-life, this could influence the response kinetics of signaling and regulatory pathways involving such proteins (see also Supplemental Discussion).
Considering that the primary transcript is the entire region between the transcriptional start and the 3' end of the transcript, all polymorphisms in this segment may affect splicing.
Thus, natural variation in the length and position of disordered segments may affect protein half-life and could serve as an underappreciated source of genetic variation with important phenotypic consequences.
The known severe visual problems primarily result from posterior segment complications, such as macular holes, choroidal neovascularization, retinal detachment, retinoschisis, etc. Regarding the anterior segment, HM may affect CT in different age groups [ 1, 2].
This study was initiated by testing the hypothesis that rhodopsin, by far the most abundant outer segment protein whose proper transport is essential for formation of this organelle, may affect trafficking and abundance of outer segment membrane proteins.
It is interesting to speculate that altering the Arg content may affect the association of the LLP segments with the lipid bilayer and perhaps the ability of the CTT to traverse the membrane during the fusion process.
