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As the mode of immortalization may affect responsiveness to TNF, we also investigated the response of primary low passage MEF derived from E14.5 embryos.
Moreover, different stresses may interact and the conditions experienced earlier may affect responsiveness to subsequent stress factors (Weinig and Delph 2001; Huber et al. 2012; von Wettberg et al. 2012).
The participants will be randomised into one of the two study groups using numbers from random length blocks, after stratification for parity (including the current pregnancy: 1 child vs >1 child) and education (non tertiary vs tertiary), as these may affect responsiveness to the intervention.
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There is an indication that temperament features may also affect responsiveness to treatment in eating disorders.
We, therefore, hypothesized that blood cell counts, which presumably reflect host conditions, may critically affect responsiveness to RT.
For patients with advanced RCC, histologic subtype is predictive of clinical outcome and of responsiveness to interleukin-2 therapy and may also affect responsiveness to tyrosine kinase inhibitors such as sunitinib and sorafanib [ 3- 10].
These data indicate that such cytokines may affect the responsiveness of cancer cells to pharmaceutical agents, which conduce to the generation of drug-resistant strains, constituting the origin of recurrence.
miRNAs may affect the responsiveness of cells to signaling molecules such as TGFβ, Wnt, Notch, and epidermal growth factor [ 67].
Human exposure to genistein may affect the responsiveness and sensitivity to other xenobiotics, particularly environmental estrogenic chemicals (You et al. 2002) and other endocrine-active dietary contaminants.
The current study clearly showed that characteristics of OA patients and more expecially obesity may affect the responsiveness of cultured chondrocytes to leptin.
Additionally, some tools, such as EQ-5D-3L, showed a high ceiling effect, for example, which may affect their responsiveness in monitoring the outcomes of ART.
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