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The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may affect replication events.
OPs target the developing nervous system (Garcia et al. 2002; Johnson et al. 1998), and chlorpyrifos may affect replication and differentiation of glial cells (Garcia et al. 2001).
Given the ease of the interconversion of the enal- N-dG cross-linked species in vitro, they likely represent a substantial fraction of enal-induced adducts in cellular DNA and may affect replication, repair, and other biological processes.
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Our results suggest that anti-inflammatory drugs may affect the replication of adenovirus, which might be relevant in case of replication associated side effects.
In conclusion, we speculate that cross-talk between viral RNAs and host mRNAs via common miRNA response elements forms complex networks during virus infection, which may affect viral replication, persistence, and pathogenesis.
It could be that changes in adipose tissue that occur in obesity, such as effects on adipokine or oxygen levels, may affect preadipocyte replication and differentiation [35], [36].
Mutations of D-loop do not directly affect the structure and function of any particular protein encoded by mtDNA but may affect mtDNA replication and transcription.
Animal studies have demonstrated that silica exposure may affect DNA replication, gene expression, and repair (Ding et al, 2002; Fubini and Hubbard, 2003).
Recent studies suggest that microsatellites play an important, direct role in genome evolution because microsatellites may affect DNA replication, translation and gene expression [ 13– 15].
Alcohol can target these signaling platforms and may exert detrimental effects on lipid rafts that contain several putative HCV receptors, which may affect HCV replication and survival of HCV-infected cells.
We have also discussed the possibility that A51R might be involved in the known perturbation of endosomal trafficking during VACV infection (Schepis et al., 2006) and that future studies should investigate if A51R-mediated perturbation of MT-dependent endosomal trafficking may affect VSV/SINV replication in L. dispar cells.
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