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New standardized measures for the assessment of suicidal behavior and ideation have been designed to improve identification and clinical management and have recently been effectively disseminated, which may affect recommendations in future guidelines [ 6].
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In the setting of LABC, the risk of axillary and internal mammary node metastases is higher, as is the risk for occult sites of malignant disease which may affect therapeutic recommendations.
Second, when developing guidelines, it seems sensible to take the required time investment of recommendations into account, since this may affect the likelihood that recommendations are followed.
How motivated the patient is to engage in treatment recommendations may affect the way a person carries out the program.
Understanding how different adjustments to childhood immunization recommendations may affect vaccine series completion, when changes are needed, is important because such changes have become more frequent in recent years due to vaccine shortages and new vaccines.
Factors that may reduce the direct application of study findings to the Australian or more local settings include organisational factors (e.g. availability of trained staff, clinic time, specialised equipment, tests or other resources) and cultural factors (e.g. attitudes to health issues, including those that may affect compliance with the recommendation).
This aspect remains critical, as it has been shown that conflicts of interest among authors of guidelines are very common and may affect the quality of final recommendations [23, 29, 30, 31].
This is a critical aspect, as it has been shown that conflicts of interest among authors of such guidelines are very common and may affect the quality of final recommendations [18, 24, 25, 26].
This should aid in the interpretation of the strength of the recommendations and may affect clinical decision-making due to diverse values and preferences of individuals implementing the interventions.
Mistrust of healthcare providers is more common among Blacks and Hispanics than Whites [ 26, 27], which may affect their trust in physicians' recommendations for LDKT and cause suspicion of LDKT itself [ 26, 28, 29].
We will discuss factors that may affect the PM endpoints and provide recommendations for future studies involving susceptible populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com